Werner syndrome

Concept

Werner syndrome

Genetic disease that causes accelerated aging due to mutations in the WRN gene.

It is a rare genetic disease, inherited in an autosomal recessive manner, that causes accelerated aging and the early onset of age-associated conditions.

It is caused by mutations in the WRN gene, which encodes a protein with helicase and exonuclease activity involved in DNA maintenance and repair. Without it, cells accumulate genetic damage more rapidly.

The video explains that the mutations occur in the Werner gene, responsible for producing a protein of the helicase family, and that without its proper function cells accumulate genetic damage that accelerates aging and increases the risk of cancer and diabetes.

Relations

• Helicase → its mutation causes → Werner syndrome
  Evidence

  Sources · original ES transcript

  • The Rule Behind All Life | The Central Dogma8:26

    mutaciones en el gen Werner, encargado de producir la proteína Werner de la familia de las helicasas.

Sources · original ES transcript

• The Rule Behind All Life | The Central Dogma8:26

  El síndrome de Werner es una rara enfermedad genética que provoca envejecimiento prematuro debido a las mutaciones en el gen Werner, encargado de producir la proteína Werner de la familia de las helicasas. Sin el correcto funcionamiento de esta proteína, las células acumulan daños genéticos que aceleran el envejecimiento y aumentan el riesgo de enfermedades como cáncer y diabetes.