Entity
Topoisomerase
Enzyme that starts DNA replication by relieving tension in the helix.
It is an enzyme that modifies DNA topology through transient cuts and subsequent resealing of one or both strands. These reactions alter supercoiling and resolve torsional stresses in genetic material.
Topoisomerases are essential during replication, transcription, and chromosome segregation, processes that require DNA to be separated or reorganized. They are also important targets of antibiotics and anticancer drugs.
This video calls it DNA gyrase and explains that it releases the tension that starts replication, cutting the helix and rejoining it. It presents it as the enzyme that resolves the tension generated by helicase as it separates the strands to open the replication fork.
Relations
- Topoisomerase → relieves tension in → DNA replication
Evidence
Sources · original ES transcript
- The Rule Behind All Life | The Central Dogma5:11
La replicación del ADN inicia con una tensión que hay que resolver. La ADN girasa la libera
- The Rule Behind All Life | The Central Dogma5:11
Sources · original ES transcript
- The Rule Behind All Life | The Central Dogma5:11
La replicación del ADN inicia con una tensión que hay que resolver. La ADN girasa la libera: corta la hélice y vuelve a unirla.
- The Rule Behind All Life | The Central Dogma5:16
La ADN girasa la libera: corta la hélice y vuelve a unirla.