Rho factor

Entity

Rho factor

Protein that uses ATP to destabilize RNA polymerase and terminate transcription.

It is a protein with ATPase and helicase activity that binds a specific sequence of the nascent RNA to trigger termination of transcription.

It acts in one of the two main mechanisms of transcriptional termination in bacteria, rho-dependent termination, which does not require the formation of a hairpin in the RNA, unlike the independent mechanism.

The video explains that it binds a rut sequence of the transcribed RNA and that, using ATP, it advances until it reaches RNA polymerase, destabilizing it and releasing the transcript.

Relations

• Rho factor → destabilizes → RNA polymerase
  Evidence

  Sources · original ES transcript

  • The Rule Behind All Life | The Central Dogma11:03

    que con el uso de ATP avanzará hasta alcanzar a la RNA polimerasa, desestabilizándola y liberando el transcrito.

Sources · original ES transcript

• The Rule Behind All Life | The Central Dogma10:50

  Y se dice terminación rho dependiente cuando la RNA polimerasa sintetiza una secuencia rut, sitio donde en el ARN transcrito se unirá el factor rho, que con el uso de ATP avanzará hasta alcanzar a la RNA polimerasa, desestabilizándola y liberando el transcrito.