Entity
Promoter
DNA sequence that signals RNA polymerase where to begin transcribing a gene.
It is a DNA sequence located before the start site of a gene that is recognized by transcription factors and by RNA polymerase to position the start of RNA synthesis.
It determines which genes are transcribed and how efficiently, making it one of the main control points of gene expression in all organisms.
The video states that in bacteria it is characterized by two consensus sequences, the −35 box and the −10 box or Pribnow box, and that its recognition by the sigma factor forms a closed complex that then opens to expose the +1 start site.
Relations
- Sigma factor → recognizes → Promoter
Evidence
Sources · original ES transcript
- The Rule Behind All Life | The Central Dogma9:00
el factor sigma de la ARN polimerasa se une a un promotor caracterizado por dos secuencias consenso, la caja −35 y la caja −10, o caja de Pribnow.
- The Rule Behind All Life | The Central Dogma9:00
Sources · original ES transcript
- The Rule Behind All Life | The Central Dogma9:00
un promotor caracterizado por dos secuencias consenso, la caja −35 y la caja −10, o caja de Pribnow.
- The Rule Behind All Life | The Central Dogma9:17
Esta unión forma un complejo cerrado que, gracias a la acción del factor sigma, pasa a complejo abierto al separarse las dos hebras de ADN, generando una pequeña burbuja de transcripción de unas 12 a 15 pares de bases. Con el sitio de inicio +1 expuesto,