DNA polymerase I

Entity

DNA polymerase I

Enzyme that replaces RNA primers with DNA during bacterial replication.

It is a bacterial DNA polymerase with 5′ to 3′ exonuclease activity in addition to its polymerase activity, which lets it remove nucleic-acid stretches ahead of it while synthesizing DNA.

During replication it replaces RNA primers with DNA and participates in repairing damage to genetic material. It is far less processive than DNA polymerase III and acts mainly on short stretches.

The video notes that it removes the RNA primers from the Okazaki fragments and replaces them with DNA nucleotides, a task required because those primers contain uracil instead of thymine.

Relations

• DNA polymerase I → replaces → Primer
  Evidence

  Sources · original ES transcript

  • The Rule Behind All Life | The Central Dogma6:42

    la DNA polimerasa I, que elimina los primers de ARN y los sustituye por nucleótidos de ADN.

Sources · original ES transcript

• The Rule Behind All Life | The Central Dogma6:30

  Estos fragmentos inician con el ARN de los cebadores que, al contener uracilo en lugar de timina, deben ser reemplazados por ADN para asegurar la fidelidad genética. Esta tarea es realizada por la DNA polimerasa I, que elimina los primers de ARN y los sustituye por nucleótidos de ADN.