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Discovery of reverse transcriptase (1970)

In 1970, Baltimore and Temin discovered reverse transcriptase, an exception to the central dogma.

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Discovery of reverse transcriptase (1970)

In 1970, Baltimore and Temin discovered reverse transcriptase, an exception to the central dogma.

In 1970, David Baltimore and Howard Temin independently discovered reverse transcriptase, an enzyme capable of synthesizing DNA from RNA.

The finding showed that genetic information can also flow from RNA to DNA, which required qualifying the popular formulation of the central dogma without invalidating its original restriction on flow from proteins. Baltimore and Temin received the Nobel Prize in Physiology or Medicine in 1975.

The video presents this milestone as a disruptive revelation: there are viruses capable of transforming RNA into DNA, showing that information can flow in reverse and giving reverse transcription its name as an exception to the central dogma.

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