Entity
Sigma factor
Subunit of bacterial RNA polymerase that recognizes the promoter and initiates transcription.
It is a subunit that transiently associates with the core of bacterial RNA polymerase and gives it specificity to recognize promoter sequences.
It is indispensable for the initiation of transcription in bacteria: without it, RNA polymerase cannot locate the correct starting site of a gene. Several alternative sigma factors allow the cell to activate different sets of genes depending on conditions.
The video states that, together with RNA polymerase, it binds a promoter characterized by the −35 box and the −10 box or Pribnow box, forming a closed complex that then opens, and that it is released after about 10 nucleotides have been synthesized, leaving the enzymatic core to continue elongation.
Relations
- Sigma factor → recognizes → Promoter
Evidence
Sources · original ES transcript
- The Rule Behind All Life | The Central Dogma9:00
el factor sigma de la ARN polimerasa se une a un promotor caracterizado por dos secuencias consenso, la caja −35 y la caja −10, o caja de Pribnow.
- The Rule Behind All Life | The Central Dogma9:00
- Sigma factor → guides → RNA polymerase
Evidence
Sources · original ES transcript
- The Rule Behind All Life | The Central Dogma9:42
Tras sintetizar aproximadamente 10 nucleótidos, el factor sigma se libera, dejando al núcleo enzimático continuar la elongación.
- The Rule Behind All Life | The Central Dogma9:42
Sources · original ES transcript
- The Rule Behind All Life | The Central Dogma9:00
La transcripción del ADN comienza cuando el factor sigma de la ARN polimerasa se une a un promotor caracterizado por dos secuencias consenso, la caja −35 y la caja −10, o caja de Pribnow.
- The Rule Behind All Life | The Central Dogma9:42
Tras sintetizar aproximadamente 10 nucleótidos, el factor sigma se libera, dejando al núcleo enzimático continuar la elongación.