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Primase

Enzyme that synthesizes the RNA primers needed to replicate DNA.

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Primase

Enzyme that synthesizes the RNA primers needed to replicate DNA.

It is a specialized RNA polymerase that synthesizes short RNA primers from a DNA template. It provides the free 3′-OH end required by DNA polymerases to initiate elongation.

Primase makes the initiation of DNA synthesis possible at the replication fork and acts repeatedly on the lagging strand. Its activity is integrated with helicases and other replisome proteins.

The video shows that, at the replication fork, it synthesizes a small RNA fragment called a primer, which marks the starting point of synthesis of the new strand and on which DNA polymerase III depends to begin adding nucleotides.

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Sources · original ES transcript

  • The Rule Behind All Life | The Central Dogma5:49
    En la horquilla de replicación, la primasa sintetiza un pequeño fragmento de ARN llamado cebador o primer, que sirve como punto de inicio para la síntesis de la nueva cadena. La DNA polimerasa III necesita del primer para poder comenzar a añadir nucleótidos complementarios a la cadena molde, siempre haciéndolo en dirección 5′ a 3′.
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