Glucose 6-phosphate

Entity

Glucose 6-phosphate

First product of glycolysis, formed by phosphorylating glucose.

It is a phosphate ester of glucose, formed by phosphorylation of carbon 6, that acts as a metabolic intermediate. Its negative charge prevents it from freely crossing the plasma membrane.

Glucose 6-phosphate is a branch point between glycolysis, glycogen synthesis, and the pentose phosphate pathway. It therefore integrates the energetic use of glucose with production of reducing equivalents and biosynthetic precursors.

The video states that it is produced in the first reaction when hexokinase transforms glucose. It also explains that it can be diverted into the pentose phosphate pathway, where it supplies NADPH and ribose 5-phosphate, and that it inhibits hexokinase itself.

Relations

• Glucose → is converted into → Glucose 6-phosphate
  Evidence

  Sources · original ES transcript

  • The 10 Reactions That Turn Glucose Into Energy | Glycolysis3:35

    En la primera reacción, la glucosa es transformada a glucosa 6-fosfato

• Glucose 6-phosphate → inhibits → Hexokinase
  Evidence

  Sources · original ES transcript

  • The 10 Reactions That Turn Glucose Into Energy | Glycolysis6:05

    Estas enzimas son la hexoquinasa, que es inhibida por glucosa 6-fosfato, su propio producto, evitando que las células sigan captando y fosforilando glucosa cuando ya tienen suficiente.

• The 10 Reactions That Turn Glucose Into Energy | Glycolysis → mentions → Glucose 6-phosphate
  Evidence

  Sources · original ES transcript

  • The 10 Reactions That Turn Glucose Into Energy | Glycolysis3:35

    En la primera reacción, la glucosa es transformada a glucosa 6-fosfato por medio de la enzima hexoquinasa, la cual usa magnesio como cofactor.

Sources · original ES transcript

• The 10 Reactions That Turn Glucose Into Energy | Glycolysis3:35

  En la primera reacción, la glucosa es transformada a glucosa 6-fosfato por medio de la enzima hexoquinasa, la cual usa magnesio como cofactor.