Person
Francis Crick
Scientist who formulated the central dogma of molecular biology in 1958.
He was a British molecular biologist, born in 1916 and deceased in 2004, associated with the Cavendish Laboratory at the University of Cambridge and the Salk Institute. His work addressed the structure and transmission of genetic information.
He is recognized, together with James Watson, for proposing the DNA double helix and received the 1962 Nobel Prize in Physiology or Medicine with Watson and Maurice Wilkins. He also formulated the central dogma of molecular biology.
The video recounts that, after the structure of DNA was solved, Crick noticed a missing piece, translation, and postulated that information originated in DNA, traveled through RNA, and culminated in proteins, always in a single direction, a scheme he called the central dogma in 1958. It also notes that when, in 1970, the press announced that the central dogma had fallen after the discovery of reverse transcription, Crick responded in Nature clarifying that he had never said RNA could not turn back into DNA, and that what the dogma forbade was information leaving a protein and returning to a nucleic acid.
Relations
- Francis Crick → was behind → Central dogma named (1958)
Evidence
Sources · original ES transcript
- The Rule Behind All Life | The Central Dogma1:58
Postuló que la información nacía en el ADN, viajaba por el ARN y culminaba en las proteínas, siempre en un solo sentido. Una vez convertida en proteína, era imposible reescribir el ADN. Crick llamó a este concepto el dogma central en 1958.
- The Rule Behind All Life | The Central Dogma1:58
- Francis Crick → received → Nobel Prize for the structure of DNA (1962)
Evidence
Sources · original ES transcript
- The Rule Behind All Life | The Central Dogma1:38
Ese premio Nobel fue la gloria definitiva de Watson, Crick y Wilkins,
- The Rule Behind All Life | The Central Dogma1:38
Sources · original ES transcript
- The Rule Behind All Life | The Central Dogma1:51
Con la estructura resuelta, Crick notó que faltaba una pieza clave: la traducción.
- The Rule Behind All Life | The Central Dogma1:58
Postuló que la información nacía en el ADN, viajaba por el ARN y culminaba en las proteínas, siempre en un solo sentido. Una vez convertida en proteína, era imposible reescribir el ADN. Crick llamó a este concepto el dogma central en 1958.
- The Rule Behind All Life | The Central Dogma23:34
Crick respondió ese mismo año en Nature, y lo que escribió fue que nunca había dicho que el ARN no pudiera volver a ADN. Lo que el dogma central prohibía era otra cosa, y es que la información saliera de una proteína y regresara a un ácido nucleico.